Expert consensus on vaccination against new coronavirus pneumonia in peri-pregnancy women

In the initial phase 3 clinical trial of the new coronavirus pneumonia (coronavirus disease 2019, COVID-19) vaccine, pregnant and lactating women were not included, resulting in the current effectiveness of COVID-19 vaccination in pregnant and lactating women Data on sex and safety are extremely limited. Since the end of 2020, relevant domestic and foreign government departments and academic associations have issued some consensus or guidance on the vaccination of COVID-19, including those during pregnancy, lactation or planned pregnancy (naturally or with assisted reproductive technology). Females, but due to the timing of the release and other reasons, there are different opinions on women's vaccination against COVID-19 during the special period mentioned above. This expert consensus is based on the latest research progress at home and abroad, recommendations from relevant institutions, and relevant policies and regulations in my country, and was formed after discussions by experts. Its purpose is to provide guidance on the vaccination of COVID-19 vaccines for women in my country during pregnancy, pregnancy, and lactation.

Nonlinear dynamic mechanism of regional air pollution during the COVID-19 lockdown

Based on hourly concentration of PM2.5 and O3 during the epidemic period（January 24, 2020 to May 31, 2020） in Changsha, Zhuzhou and Xiangtan, the diurnal patterns, long-term persistence, multifractality and self-organization evolution dynamics of these two pollutants were studied to reveal the internal dynamic mechanism of the occurrence and evolution of heavy pollution events during the epidemic period. Firstly, the diurnal patterns of PM2.5 and O3 concentrations were investigated. It showed that O3 showed a single peak of high concentration in the daytime and low in the night, while PM2.5 showed a single lowest peak concentration in the day and high in the night, which was different from the pattern in non-epidemic periods. Furthermore, detrended fluctuation analysis（DFA）, the multifractal detrended fluctuation analysis（MFDFA） and probability statistical analysis were applied to study the long-term persistence, multi-fractal structure of PM2.5 and O3 series. The results showed that PM2.5 and O3 series had significant long-term persistence characteristics and strong multi-fractal structures for the three cities. Meanwhile, detrended cross-correlation analysis（DCCA） and multifractal detrended cross-correlation analysis（MFDCCA） were conducted to estimate the cross-correlations between PM2.5 and O3 series. Long-term persistence as well as multifractal features at different time scales was also observed in PM2.5-O3 cross-correlations. Next, nonlinear analysis results obtained during epidemic period were compared with those obtained in the same periods of non-epidemic years of 2019 and 2018. Finally, based on the self-organized criticality（SOC） theory, the internal dynamic law of spatial and temporal evolution of PM2.5 and O3 series was discussed. Combined with the typical regional meteorological characteristics, it was found that the intrinsic dynamic mechanism of SOC may be one of the leading mechanisms of heavy air pollution episodes during the COVID-19 lockdown period. During the epidemic period, PM2.5 and O3 concentrations did not evolve independently but remained complex interactions. Under the stable meteorological conditions, the nonlinear coupling effect inside the air combined pollution might reach the dynamic critical state, thus, lead to the risk of heavy air pollution in Greater Changsha Metropolitan Region during the epidemic period.

Identification of potential antiviral compounds against SARS-CoV-2 structural and non structural protein targets: A pharmacoinformatics study of the CAS COVID-19 dataset.

SARS-CoV-2 is a newly discovered virus which causes COVID-19 (coronavirus disease of 2019), initially documented as a human pathogen in 2019 in the city of Wuhan China, has now quickly spread across the globe with an urgency to develop effective treatments for the virus and emerging variants. Therefore, to identify potential therapeutics, an antiviral catalogue of compounds from the CAS registry, a division of the American Chemical Society was evaluated using a pharmacoinformatics approach. A total of 49,431 compounds were initially recovered. After a biological and chemical curation, only 23,575 remained. A machine learning approach was then used to identify potential compounds as inhibitors of SARS-CoV-2 based on a training dataset of molecular descriptors and fingerprints of known reported compounds to have favorable interactions with SARS-CoV-2. This approach identified 178 compounds, however, a molecular docking analysis revealed only 39 compounds with strong binding to active sites. Downstream molecular analysis of four of these compounds revealed various non-covalent interactions along with simultaneous modulation between ligand and protein active site pockets. The pharmacological profiles of these compounds showed potential drug-likeness properties. Our work provides a list of candidate anti-viral compounds that may be used as a guide for further investigation and therapeutic development against SARS-CoV-2.

Expert Consensus on the Management Process of Gynecological Emergency under the Regular Epidemic Prevention and Control of COVID-19

At present, China is in the stage of the COVID-19 epidemic where regular prevention and control measures are required to contain the spread of disease. Reports of new sporadic cases are still widespread across China and medical personnel remain at high risk of exposure to infection. This is especially the case for medical staff working within emergency departments. Most gynecological emergency cases are complex and a high proportion require emergency surgical treatment. By referring to national regulations and requirements on COVID-19 prevention and control, and by summarizing our experiences in the battle against COVID-19 within Wuhan, this consensus report provides recommendations on the triage, reception, consultation, admission and surgical management of gynecological emergency patients. We also make suggestions for the environmental layout and disinfection and the medical waste management. This consensus aims to optimize the diagnosis and treatment process of gynecological emergency patients and reduce the exposure risk of medical staff within the current context of routine COVID-19 prevention and control.